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ProductsBack/LY-294,002 [154447-36-6]
Chemical Structure
Chemical Structure
Chemical Structure

LY-294,002 [154447-36-6]

Research Use Only
AG-CR1-0108
AdipoGen Life Sciences
CAS Number154447-36-6
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Product group Chemicals
Estimated Purity>99% (NMR)
Molecular Weight307.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    LY-294,002 [154447-36-6]
  • Delivery Days Customer
    10
  • CAS Number
    154447-36-6
  • Certification
    Research Use Only
  • Estimated Purity
    >99% (NMR)
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C19H17NO3
  • Molecular Weight
    307.4
  • Scientific Description
    Chemical. CAS: 154447-36-6. Formula: C19H17NO3. MW: 307.4. Potent, cell permeable, highly specific, reversible PI(3)K (phosphoinositide 3-kinase) inhibitor. pan-class I / II / III PI3K inhibitor. Acts on the ATP-binding site of the enzyme. In solution more stable than wortmannin. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Autophagy inhibitor (autophagosome formation). Inhibitor of BET bromodomain proteins BRD2, BRD3 and BRD4. - Potent, cell permeable, highly specific, reversible PI(3)K (phosphoinositide 3-kinase) inhibitor. pan-class I / II / III PI3K inhibitor. Acts on the ATP-binding site of the enzyme. In solution more stable than wortmannin. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Autophagy inhibitor (autophagosome formation). Inhibitor of BET bromodomain proteins BRD2, BRD3 and BRD4.
  • SMILES
    O=C1C=C(OC2=C(C=CC=C12)C1=CC=CC=C1)N1CCOCC1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4- morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002): C.J. Vlahos, et al.; J. Biol. Chem. 269, 5241 (1994)
  • Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase: C.J. Vlahos, et al.; J. Immunol. 154, 2413 (1995)
  • Pim-1 Ligand-bound Structures Reveal the Mechanism of Serine/Threonine Kinase Inhibition by LY294002: M.D. Jacobs, et al.; J. Biol. Chem. 280, 13728 (2005)
  • LY294002 and LY303511 Sensitize Tumor Cells to Drug-Induced Apoptosis via Intracellular Hydrogen Peroxide Production Independent of the Phosphoinositide 3-Kinase-Akt Pathway: T.W. Poh & S. Pervaiz; Cancer Res. 65, 6264 (2005)
  • LY294,002, a specific inhibitor of PI3K/Akt kinase pathway, antagonizes P-glycoprotein-mediated multidrug resistance: M. Barancík, et al.; Eur. J. Pharm. Sci. 29, 426 (2006)
  • A role for Akt in the rapid regulation of inflammatory and apoptotic pathways in mouse bladder: F.J. Tamarkin, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 373, 349 (2006)
  • Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors: M. Hayakawa, et al.; Bioorg. Med. Chem. 15, 5837 (2007)
  • The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains: A. Dittmann, et al.; ACS Chem. Biol. 9, 495 (2014)