Prexasertib [1234015-52-1]

MedChem Express

Prexasertib [1234015-52-1]

10

1234015-52-1

Research Use Only

98.03%

C18H19N7O2

365.39

Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of 50=8 nM) and RSK1 (IC50=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity.

NCCCOC(C=CC=C1OC)=C1C2=CC(NC3=NC=C(C#N)N=C3)=NN2

2°C to 8°C,-20°C,-80°C

12352200