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Merestinib dihydrochloride [1206801-37-7]

Research Use Only
HY-15514A
MedChem Express
CAS Number1206801-37-7
Product group Chemicals
Estimated Purity98.12%
Molecular Weight625.45
Price on request
Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Merestinib dihydrochloride [1206801-37-7]
  • Delivery Days Customer
    10
  • CAS Number
    1206801-37-7
  • Certification
    Research Use Only
  • Estimated Purity
    98.12%
  • Molecular Formula
    C30H24Cl2F2N6O3
  • Molecular Weight
    625.45
  • Scientific Description
    Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM).
  • SMILES
    [H]Cl.[H]Cl.O=C(C1=CC=C(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC5=C(N(C)N=C5)C=C4C6=CNN=C6)C(F)=C3
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200