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LY2886721 [1262036-50-9]

Research Use Only
HY-13240
MedChem Express
CAS Number1262036-50-9
Product group Chemicals
Estimated Purity99.42%
Molecular Weight390.41
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Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    LY2886721 [1262036-50-9]
  • Delivery Days Customer
    10
  • CAS Number
    1262036-50-9
  • Certification
    Research Use Only
  • Estimated Purity
    99.42%
  • Molecular Formula
    C18H16F2N4O2S
  • Molecular Weight
    390.41
  • Scientific Description
    LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimers disease treatment.
  • SMILES
    FC1=CN=C(C=C1)C(NC2=CC=C(C([C@@]34[C@]([H])(CSC(N)=N4)COC3)=C2)F)=O
  • Storage Instruction
    -20°C,-80°C
  • UNSPSC
    12352200