LY3214996 [1951483-29-6]

MedChem Express

LY3214996 [1951483-29-6]

10

1951483-29-6

Research Use Only

99.85%

C22H27N7O2S

453.56

Temuterkib (LY3214996) is a highly selective inhibitor of ERK1 and ERK2, with IC50 of 5 nM for both enzymes in biochemical assays. Temuterkib potently inhibits cellular p-RSK1 in BRAF and RAS mutant cancer cell lines. Temuterkib shows potent antitumor activities in cancer models with MAPK pathway alterations.

O=C(C(C=C(C1=NC(NC2=CC=NN2C)=NC=C1)S3)=C3C4(C)C)N4CCN5CCOCC5

2°C to 8°C,-20°C,-80°C

12352200