Mavatrep [956274-94-5]

MedChem Express

Mavatrep [956274-94-5]

10

956274-94-5

Research Use Only

98%

C25H21F3N2O

422.44

Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain.

OC(C)(C)C1=CC=CC=C1C2=CC=C3N=C(/C=C/C4=CC=C(C(F)(F)F)C=C4)NC3=C2

2°C to 8°C,-20°C,-80°C

12352200