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ProductsBack/MnTMPyP . pentachloride [100012-18-8]
Chemical Structure
Chemical Structure
Chemical Structure

MnTMPyP . pentachloride [100012-18-8]

Research Use Only
AG-CR1-0026
AdipoGen Life Sciences
Estimated Purity>96% (Microanalysis)
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Product group Chemicals
Molecular Weight909
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    MnTMPyP . pentachloride [100012-18-8]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >96% (Microanalysis)
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C44H36MnN8Cl5
  • Molecular Weight
    909
  • Scientific Description
    Cell permeable superoxide dismutase (SOD) mimetic [1, 2, 4]. Peroxynitrite scavenger [3]. Displays a protective effect against H2O2 mediated injury [5]. Neuroprotective [6]. Oxidative stress inhibitor [7]. Apoptosis inhibitor [7]. Reduces inflammation [8]. - Chemical. CAS: 100012-18-8. Formula: C44H36MnN8Cl5. MW: 909. Cell permeable superoxide dismutase (SOD) mimetic. Peroxynitrite scavenger. Displays a protective effect against H2O2 mediated injury. Neuroprotective. Oxidative stress inhibitor. Apoptosis inhibitor. Reduces inflammation.
  • SMILES
    C[N+]1=CC=C(C=C1)C1=C2C=CC3=[N]2C24N5C1=CC=C5C(=C1C=CC(C(=C5C=CC(N25)=C3C2=CC=[N+](C)C=C2)C2=CC=[N+](C)C=C2)=[N]41)C1=CC=[N+](C)C=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994)
  • Superoxide scavenging by Mn(II/III) tetrakis (1-methyl-4-pyridyl) porphyrin in mammalian cells: P.R. Gardner, et al.; Arch. Biochem. Biophys. 325, 20 (1996)
  • Molecular actions of a Mn(III)Porphyrin superoxide dismutase mimetic and peroxynitrite scavenger: reaction with nitric oxide and direct inhibition of NO synthase and soluble guanylyl cyclase: S. Pfeiffer, et al.; Mol. Pharmacol. 53, 795 (1998)
  • The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium- 2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic: Batinic-Haberle, et al.; J. Biol. Chem. 273, 24521 (1998)
  • Protective properties of tin- and manganese-centered porphyrins against hydrogen peroxide-mediated injury in rat astroglial cells: B.E. Dwyer, et al.; J. Neurochem. 71, 2497 (1998)
  • Neuroprotective effect of MnTMPyP, a superoxide dismutase/catalase mimetic in global cerebral ischemia is mediated through reduction of oxidative stress and DNA fragmentation: S.S. Sharma & S. Gupta; Eur. J. Pharmacol. 561, 72 (2007)
  • MnTMPyP, a cell-permeant SOD mimetic, reduces oxidative stress and apoptosis following renal ischemia-reperfusion: H.L. Liang, et al.; Am. J. Physiol. Renal Physiol. 296, F266 (2009)
  • MnTMPyP, a superoxide dismutase/catalase mimetic, decreases inflammatory indices in ischemic acute kidney injury: J. Mortensen, et al.; Inflamm. Res. 60, 299 (2011)