MRK-016 [342652-67-9]

MedChem Express

MRK-016 [342652-67-9]

10

342652-67-9

98.57%

C17H20N8O2

368.39

MRK-016 is a selective, orally bioavailable inverse agonist of GABAA alpha5 receptor, with an EC50 of 3 nM for GABAA alpha5, and Kis of 0.83, 0.85, 0.77 and 1.4 nM for human GABAA alpha1beta3gamma2, GABAA alpha2beta3gamma2, GABAA alpha3beta3gamma2, and GABAA alpha5beta3gamma2, respectively; MRK-016 also readily penetrates the CNS.

CN1N=CN=C1COC2=NN3C(C4=NOC(C)=C4)=NN=CC3=C2C(C)(C)C

2°C to 8°C,-20°C,-80°C

12352200