N-Desmethylclozapine [6104-71-8]

MedChem Express

N-Desmethylclozapine [6104-71-8]

10

6104-71-8

99.66%

C17H17ClN4

312.8

N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a delta-opioid agonist.

ClC1=CC=C2C(N=C(N3CCNCC3)C4=CC=CC=C4N2)=C1

2°C to 8°C,-20°C,-80°C

12352200