Necrosulfonamide [1360614-48-7]

MedChem Express

Necrosulfonamide [1360614-48-7]

10

1360614-48-7

98%

C18H15N5O6S2

461.47

Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis.

O=C(NC1=CC=C(S(=O)(NC2=NC=CN=C2OC)=O)C=C1)/C=C/C3=CC=C([N+]([O-])=O)S3

2°C to 8°C,-20°C,-80°C

12352200