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NKL 22 [537034-15-4]

Research Use Only
HY-100384
MedChem Express
CAS Number537034-15-4
Product group Chemicals
Estimated Purity97.27%
Molecular Weight325.4
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Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    NKL 22 [537034-15-4]
  • Delivery Days Customer
    10
  • CAS Number
    537034-15-4
  • Certification
    Research Use Only
  • Estimated Purity
    97.27%
  • Molecular Formula
    C19H23N3O2
  • Molecular Weight
    325.4
  • Scientific Description
    NKL 22 (compound 4b) is a potent and selective inhibitor of histone deacetylases (HDAC), with an IC50 of 199 and 69 nM for HDAC1 and HDAC3, respectively. NKL 22 exhibits selectivity over HDAC2/4/5/7/8 (IC50≥1.59 microM). NKL 22 ameliorates the disease phenotype and transcriptional abnormalities in Huntingtons disease transgenic mice.
  • SMILES
    O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200