Nocodazole [31430-18-9]

Catalog number: AG-CR1-0019-M005
Brand: AdipoGen Life Sciences
Packing: 5 mg
Other sizes: 10 mg
25 mg
50 mg
Price: € 35.00
Expected delivery time: 7 days
Quantity:
Chemical Structure
Chemical Structure...

Product specifications for - Nocodazole [31430-18-9]

Overview: 
Product group: Chemicals
Category: Other
CAS No.: 31430-18-9
Properties: 
Purity: >98% (NMR)
Molecular Formula: C14H11N3O3S
Molecular weight: 301.3
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Storage instructions: Store at +4°C
Scientific information: 
Scientific info: Chemical. CAS: 31430-18-9. Formula: C14H11N3O3S. MW: 301.3. Microtubule inhibitor. Antitumor compound. Mitosis inhibitor. Arrests the cell cycle at G2/M phase. Promotes tubulin depolymerization. Induces fragmentation of the Golgi complex. Inhibits the T cell antigen receptor. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway. Apoptosis inducer. Autophagy inhibition through prevention of autophagosome-lysosome fusion. - Microtubule inhibitor. Antitumor compound. Mitosis inhibitor. Arrests the cell cycle at G2/M phase. Promotes tubulin depolymerization. Induces fragmentation of the Golgi complex. Inhibits the T cell antigen receptor. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway. Apoptosis inducer. Autophagy inhibition through prevention of autophagosome-lysosome fusion.
Safety information: 
MSDS: MSDS
Hazard information: H341, H351
R17934-NSC 238159: a new antitumor drug--I. Effect on experimental tumors and factors influencing effectiveness: G. Atassi and H.J. Tagnon; Eur. J. Cancer 11, 599 (1975) Read more
R17934-NSC238159: a new antitumor drug--II. Effect on mitotic cycle of L1210 leukemia cells in vivo and synergism with cytosine arabinoside (NSC63878): G. Atassi, et al.; Eur. J. Cancer 11, 609 (1975) Read more
Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis; M.A. Jordan, et al.; J. Cell Sci. 102, 401 (1992) Read more
Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro: R.J. Vasquez, et al.; Mol. Biol. Cell 8, 973 (1997) Read more
Recycling of golgi-resident glycosyltransferases through the ER reveals a novel pathway and provides an explanation for nocodazole-induced Golgi scattering: B. Storrie, et al.; J. Cell Biol. 143, 1505 (1998) Read more
Nocodazole inhibits signal transduction by the T cell antigen receptor: R.D. Huby, et al.; J. Biol. Chem. 273, 12024 (1998) Read more
Studies on the nocodazole-induced GTPase activity of tubulin: M.R. Mejillano, et al.; Arch. Biochem. Biophys. 336, 130 (1996) Read more
Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways: T.H. Wang, et al.; J. Biol. Chem. 273, 4928 (1998) Read more
Raf-1/MEK/MAPK pathway is necessary for the G2/M transition induced by nocodazole: C. Hayne, et al.; J. Biol. Chem. 275, 31876 (2000) Read more
Apoptosis induced by microtubule disrupting drugs in normal murine thymocytes in vitro: V. Bumbasirevic, et al.; Scanning Microsc. 9, 509 (1995) Read more