Ilginatinib hydrochloride [1239358-85-0]

MedChem Express

Ilginatinib hydrochloride [1239358-85-0]

10

1239358-85-0

98%

C21H21ClFN7

425.89

Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM).

[H]Cl.CN1N=CC(C2=CC(N[C@H](C3=CC=C(F)C=C3)C)=NC(NC4=NC=CN=C4)=C2)=C1

2°C to 8°C,-20°C,-80°C

12352200