Ilginatinib maleate [1354799-87-3]

MedChem Express

Ilginatinib maleate [1354799-87-3]

10

1354799-87-3

Research Use Only

97.04%

C25H24FN7O4

505.5

Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM).

CN1N=CC(C2=CC(N[C@H](C3=CC=C(F)C=C3)C)=NC(NC4=NC=CN=C4)=C2)=C1.O=C(O)/C=C\C(O)=O

2°C to 8°C,-20°C,-80°C

12352200