NVP 231 [362003-83-6]

MedChem Express

NVP 231 [362003-83-6]

10

362003-83-6

Research Use Only

99.57%

C25H25N3O2S

431.55

NVP 231 is a potent, specific, and reversible ceramide kinase (CerK) inhibitor(IC50=12 nM) that competitively inhibits binding of ceramide to CerK. NVP 231 induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage.

O=C(C1(C[C@@H](C2)C3)C[C@@H]3C[C@@H]2C1)NC4=CC=C5N=C(NC(C6=CC=CC=C6)=O)SC5=C4

2°C to 8°C,-20°C,-80°C

12352200