NVP-AUY922 [747412-49-3]

Catalog number: HY-10215_10mg
Brand: MedChem Express
Packing: 10 mg
Other sizes: Also available in other sizes.
Price: € 115.00
Expected delivery time: 10 days

Product specifications for - NVP-AUY922 [747412-49-3]

Product group: Chemicals
Category: Inhibitors / activators
CAS No.: 747412-49-3
Purity: >98%
Molecular Formula: C26H31N3O5
Molecular weight: 465.5414
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: AUY922 (NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90alpha/beta with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1. IC50 Value: 13 nM(HSP90alpha), 21 nM(HSP90beta) Target: HSP90 in vitro: NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. in vivo: Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERalpha, in addition to reductions in CDK4 and phospho-ERK1/2.
Safety information: 
Additional information: 
Synonyms: HY-10215; Luminespib; AUY922; VER-52296; NVP-AUY 922; AUY-922; VER 52296; VER52296
Colorectal cancer Consensus Molecular Subtypes translated to preclinical models uncover potentially targetable cancer-cell dependencies', Sveen A. Clin Cancer Res. 2017 Dec 14. Read more