NXT629 [1454925-59-7]

MedChem Express

NXT629 [1454925-59-7]

10

1454925-59-7

99.2%

C35H39N5O3S

609.78

NXT629 is a potent, selective, and competitive PPAR-alpha antagonist, with an IC50 of 77 nM for human PPARalpha, shows high selectivity over other nuclear hormone receptor, such as PPARdelta, PPARgamma, ERbeta, GR and TRbeta, IC50s are 6.0, 15, 15.2, 32.5 and >100 microM, respectively. NXT629 has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models.

O=S(C1=CC=CC=C1)(NC2=CC=C(C3=CC=C(CCCC(N4CC)=NN(CC5=CC=C(C(C)(C)C)C=C5)C4=O)C=C3)N=C2)=O

-20°C,-80°C

12352200