Narazaciclib [1357470-29-1]
HY-12624
CAS Number1357470-29-1
Product group Chemicals
Estimated Purity99.34%
Molecular Weight429.52
Overview
- SupplierMedChem Express
- Product NameNarazaciclib [1357470-29-1]
- Delivery Days Customer10
- CAS Number1357470-29-1
- CertificationResearch Use Only
- Estimated Purity99.34%
- Molecular FormulaC24H27N7O
- Molecular Weight429.52
- Scientific DescriptionNarazaciclib (ON123300), a strong and brain-penetrant multi-kinase inhibitor, inhibits CDK4 (IC50=3.9 nM), Ark5 (IC50=5 nM), PDGFRbeta (IC50=26 nM), FGFR1 (IC50=26 nM), RET (IC50=9.2 nM), and FYN (IC50=11 nM). Single agent Narazaciclib causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors. Narazaciclib inhibits CDK6 with an IC50 of 9.82 nM.
- SMILESN#CC1=CC2=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3)N=C2N(C5CCCC5)C1=O
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200