Tirabrutinib [1351636-18-4]

MedChem Express

Tirabrutinib [1351636-18-4]

10

1351636-18-4

99.14%

C25H22N6O3

454.48

Tirabrutinib (ONO-4059) is an orally active Brutons Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib irreversibly and covalently binds to BTK and inhibits aberrant B cell receptor signaling. Tirabrutinib can be used in studies of autoimmune diseases and hematological malignancies.

O=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[C@H]5CN(C(C#CC)=O)CC5

2°C to 8°C,-20°C,-80°C

12352200