ONO-4059 (analog) [1351635-67-0]

Catalog number: HY-18951_10mM
Brand: MedChem Express
Packing: 10 mM
Other sizes: 5 mg
10 mg
25 mg
50 mg
100 mg
Price: € 179.00
Expected delivery time: 7 days
Quantity:

Product specifications for - ONO-4059 (analog) [1351635-67-0]

Overview: 
Product group: Chemicals
Category: Inhibitors / activators
CAS No.: 1351635-67-0
Properties: 
Purity: >98%
Molecular Formula: C25H24N6O3
Molecular weight: 456.4965
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: The product is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor with an IC50 in the sub-nM range. IC50 value: sub-nM range [2] Target: Btk in vitro: ONO-4059 ( analog ) is a selective, once-daily, oral inhibitor of BTK, which has been shown to play a role in the survival and proliferation of malignant B-cells. ONO-4059 (analog) shows a favourable safety profile along with promising efficacy in this difficult-to-treat patient population. [1] in vivo: ONO-4059 (analog) has demonstrated anti-tumour activity in several pre-clinical models.[1] ONO-4059 (analog) potently and dose-dependently reverse clinical arthritis and prevented bone damage in the CIA model.[2]
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: HY-18951; ONO 4059 analog; ONO4059 analog