Paclitaxel [33069-62-4]

Catalog number: AG-CN2-0045-M001
Brand: AdipoGen Life Sciences
Packing: 1 mg
Other sizes: 5 mg
25 mg
100 mg
Price: € 12.00
Expected delivery time: 7 days
Chemical Structure

Product specifications for - Paclitaxel [33069-62-4]

Product group: Chemicals
Category: Other
Source: Isolated from the bark of the pacific yew tree (Taxus brevifolia).
CAS No.: 33069-62-4
Purity: >99% (HPLC)
Molecular Formula: C47H51NO14
Molecular weight: 853.9
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Anti-mitotic. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase. Apoptosis inducer through aberrant activation of cyclin-dependent kinases (CKDs) and the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK). Immunosuppressor. Immunostimulant. Antiproliferative agent for the prevention of restenosis. TRAIL sensitizer
Safety information: 
Hazard information: H315, H317, H318, H335, H361, H371, H413
Additional information: 
Synonyms: AG-CN2-0045-M001; AdipoGen Life Sciences; Taxol; BMS 181339-01; NSC 125973
Cytotoxic studies of paclitaxel (Taxol®) in human tumour cell lines: J.E. Liebmann, et al.; Br. J. Cancer 68, 1104 (1993) Read more
Taxol (paclitaxel): mechanisms of action: S.B. Horwitz; Ann. Oncol. 5, S3 (1994) (Review) Read more
Taxol (paclitaxel): a novel anti-microtubule agent with remarkable anti-neoplastic activity: R. Foa, et al.; Int. J. Clin. Lab. Res. 24, 6 (1994) (Review) Read more
Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway: C.M. Woods, et al.; Mol. Med. 1, 506 (1995) Read more
Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle: A. Jordan, et al.; Med. Res. Rev. 18, 259 (1998) Read more
How Taxol stabilises microtubule structure: L.A. Amos & J. Löwe; Chem. Biol. 6, R65 (1999) (Review) Read more
Mechanisms of Taxol-induced cell death are concentration dependent: K. Torres & S.B. Horwitz; Cancer Res. 58, 3620 (1998) Read more
Molecular effects of paclitaxel: myths and reality (a critical review): M.V. Blagosklonny & T. Fojo; Int. J. Cancer 83, 151 (1999) Read more
Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK) dependent and -independent pathways in ovarian cancer cells: T.H. Wang, et al.; J. Biol. Chem. 274, 8208 (1999) Read more
Paclitaxel-induced cell death: where the cell cycle and apoptosis come together: T.H. Wang, et al.; Cancer 88, 2619 (2000) Read more