Paclitaxel [33069-62-4]

Catalog number: HY-B0015_100mg
Brand: MedChem Express
Packing: 100 mg
Other sizes: 50 mg
10 mM
500 mg
Price: On Request
Expected delivery time: 10 days
Paclitaxel Chemical Structure
CAS No. : 33069-62-4...

Product specifications for - Paclitaxel [33069-62-4]

Product group: Chemicals
Category: Other
CAS No.: 33069-62-4
Purity: >98%
Molecular Formula: C47H51NO14
Molecular weight: 853.91
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. IC50 Value: 0.1 pM Target: microtubule in vitro: Paclitaxel inhibits non-endothelial type human cells at 104 - to 105 -fold higher concentrations, with IC50 of 1 nM-10 nM. The selectivity of Paclitaxel inhibition of cell proliferation is also species specific, as mouse ECs are not sensitive to Paclitaxel at ultra low concentrations. Inhibition of human ECs by Paclitaxel at ultra low concentrations does not affect the cellular microtubule structure, and the treated cells do not show G2/M cell cycle arrest and apoptosis, suggesting a novel but as yet unidentified mechanism of action. In an in vitro angiogenesis assay, Paclitaxel at ultra low concentrations blocks human ECs from forming sprouts and tubes in the three-dimensional fibrin matrix. In the presence of SMF, the efficient concentration of Paclitaxel on K562 cells is decreased from 50 to 10 ng/mL. The cell cycle arrest effect of Paclitaxel with or without SMF on K562 cells is correlated with DNA damage. Paclitaxel alone causes a time-dependent inhibition of CDK1 in four cell lines including A549 cells, H358, H1395 cells and H1666 cells. in vivo: The inhibition rations of Paclitaxel alone on BC-V and BC-ER tumors are 49.78% and 51.23%, respectively. Treatment of six cycles of 20 mg/kg Paclitaxel significantly reduces the percentages of Ki-67-positive cells to 20.4% in BC-V tumors and 25.1% in BC-ER tumors, respectively.
Safety information: 
Additional information: 
Synonyms: HY-B0015
Tang X, Li G, Su F, et al. HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration. Nucleic Acids Res. 2020;48(6):2912-2923. Read more
Ichimizu S, Watanabe H, Maeda H, et al. Design and tuning of a cell-penetrating albumin derivative as a versatile nanovehicle for intracellular drug delivery. J Control Release. 2018;277:23-34. Read more
Niepel M, Hafner M, Mills CE, et al. A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines. Cell Syst. 2019;9(1):35-48.e5. Read more
Wang Y, Zhang L, Wei Y, et al. Pharmacological Targeting of Vacuolar H-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020; Read more
Wang L, Liu Z, Wang L, et al. Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors. Cell Mol Immunol. 2020;17(5):496-506. Read more