Paprotrain [57046-73-8]

Name: Paprotrain [57046-73-8]
SKU: AG-CR1-3504_A27
Price: 99 EUR
Availability: InStock

AG-CR1-3504

CAS Number57046-73-8

Product group Chemicals

Estimated Purity>98% (NMR)

Molecular Weight245.3

Overview

Supplier
AdipoGen Life Sciences
Product Name
Paprotrain [57046-73-8]
Delivery Days Customer
10
CAS Number
57046-73-8
Certification
Research Use Only
Estimated Purity
>98% (NMR)
Hazard Information
Non-hazardous
Molecular Formula
C16H11N3
Molecular Weight
245.3
Scientific Description
Cell permeable and reversible kinesin-specific MKLP-2 (mitotic kinesin-like protein 2) inhibitor [1]. Inhibits the recruitment of the chromosome passenger proteins survivin and aurora B to the central spindle during anaphase chromosome segregation [1]. Moderate DYRK1A inhibitor (IC50= 5.5 microM). Lead compound [3]. - Chemical. CAS: 57046-73-8. Formula: C16H11N3. MW: 245.3. Cell permeable and reversible kinesin-specific MKLP-2 (mitotic kinesin-like protein 2) inhibitor. Inhibits the recruitment of the chromosome passenger proteins survivin and aurora B to the central spindle during anaphase chromosome segregation. Moderate DYRK1A inhibitor (IC50= 5.5 microM). Lead compound.
SMILES
[H]\C(=C(\C#N)C1=CNC2=C1C=CC=C2)C1=CN=CC=C1
Storage Instruction
2°C to 8°C,-20°C
UNSPSC
12352200

Relocation of Aurora B and Survivin from Centromeres to the Central Spindle Impaired by a Kinesin-Specific MKLP-2 Inhibitor: S. Tcherniuk, et al.; Angew. Chem. (Int'l Ed.) 49, 8228 (2010)
New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations: C. Labrière, et al.; Bioorg. Med. Chem. 24, 721 (2016)
Further investigation of paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors: C. Labrière, et al.; Eur. J. Med. Chem. 124, 920 (2016)