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ProductsBack/PD 150,606 [426821-41-2]
Chemical Structure
Chemical Structure
Chemical Structure

PD 150,606 [426821-41-2]

Research Use Only
AG-CR1-0066
AdipoGen Life Sciences
CAS Number426821-41-2
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Product group Chemicals
Estimated Purity>98% (NMR)
Molecular Weight306.1
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    PD 150,606 [426821-41-2]
  • Delivery Days Customer
    10
  • ADR Class
    6.1
  • CAS Number
    426821-41-2
  • Certification
    Research Use Only
  • Estimated Purity
    >98% (NMR)
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C9H7IO2S
  • Molecular Weight
    306.1
  • Scientific Description
    Cell permeable and selective calpain-1 and -2 inhibitor [1, 3]. Interacts with calcium-binding domain of calpain [2, 4]. Neuroprotective [2]. Ca2+-permeable AMPA receptor inhibitor [5]. Apoptosis inhibitor [6] Autophagy activator by preventing cleavage of ATG5 [7.] - Chemical. CAS: 426821-41-2. Formula: C9H7IO2S. MW: 306.1. Cell permeable and selective calpain-1 and -2 inhibitor. Interacts with calcium-binding domain of calpain. Neuroprotective. Ca2+-permeable AMPA receptor inhibitor. Apoptosis inhibitor Autophagy activator by preventing cleavage of ATG5
  • SMILES
    OC(=O)C(\S)=C\C1=CC=C(I)C=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UN Number
    UN 2811
  • UNSPSC
    12352200

References

  • Modulation of hypoxia-induced calpain activity in rat renal proximal tubules: C.L. Edelstein, et al.; Kidney Int. 50, 1150 (1996)
  • An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective: K.K. Wang, et al.; PNAS 93, 6687 (1996)
  • Alpha-mercaptoacrylic acid derivatives as novel selective calpain inhibitors: K.K. Wang, et al.; Adv. Exp. Med. Biol. 389, 95 (1996)
  • Crystal structure of calcium bound domain VI of calpain at 1.9A resolution and its role in enzyme assembly, regulation, and inhibitor binding: G.D. Lin, et al.; Nat. Struct. Biol. 4, 539 (1997)
  • An alpha-mercaptoacrylic acid derivative (PD150606) inhibits selective motor neuron death via inhibition of kainate-induced Ca2+ influx and not via calpain inhibition: L. Van den Bosch, et al.; Neuropharmacology 42, 706 (2002)
  • Calpain, an upstream regulator of thymocyte apoptosis: M.K. Squier & J.J. Cohen; J. Immunol. 158, 3690 (1997)
  • Post-translational control of IL-1beta via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53: M. Niebler, et al.; PLoS Pathog. 9, e1003536 (2013)