Nirogacestat [1290543-63-3]

MedChem Express

Nirogacestat [1290543-63-3]

10

1290543-63-3

Research Use Only

97.5%

C27H41F2N5O

489.64

Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective gamma-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers.

FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1

2°C to 8°C,-20°C,-80°C

12352200