Bio-Connect

PF-CBP1 hydrochloride [2070014-93-4 [2070014-93-4;]

Research Use Only
HY-19999A
MedChem Express
Estimated Purity95.95%
Product group Chemicals
Molecular Weight525.08
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    MedChem Express
  • Product Name
    PF-CBP1 hydrochloride [2070014-93-4 [2070014-93-4;]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    95.95%
  • Molecular Formula
    C29H37ClN4O3
  • Molecular Weight
    525.08
  • Scientific Description
    PF-CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain (CBP BRD). PF-CBP1 inhibits CREBBP and EP300 bromodomains with IC50 of 125 nM and 363 nM respectively. PF-CBP1 hydrochloride reduces LPS-induced inflammatory cytokines expression (IL-1beta, IL-6 and IFN-beta) in primary macrophages. PF-CBP1 hydrochloride also downregulates RGS4 expression cortical neurons and can be used for the research of neurological disorders, including epilepsy and parkinsons disease, et al.
  • SMILES
    CCCOC1=CC=C(CCC2=NC3=CC(C4=C(C)ON=C4C)=CC=C3N2CCN5CCOCC5)C=C1.Cl[H]
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200