PFI-2 hydrochloride [1627607-87-7]

MedChem Express

PFI-2 hydrochloride [1627607-87-7]

10

1627607-87-7

Research Use Only

96.09%

C23H26ClF4N3O3S

535.98

PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R)-PFI-2 shows high inhibiting activity with IC50 value of 2.0 nM and (S)-PFI-2 shows inhibiting activity with IC50 value of 1.0 microM. PFI-2 hydrochloride can be used for the research of chronic kidney disease and inflammation response in the development of renal fibrosis.

O=S(C1=CC2=C(CNCC2)C(F)=C1)(N[C@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)=O.[H]Cl

2°C to 8°C,-20°C,-80°C

12352200