Phenformin (hydrochloride) [834-28-6]

Catalog number: HY-16397A_10mM
Brand: MedChem Express
Packing: 10 mM
Other sizes: 1 g
10 g
5 g
50 g
Price: € 83.00
Expected delivery time: 10 days

Product specifications for - Phenformin (hydrochloride) [834-28-6]

Product group: Chemicals
Category: Other
CAS No.: 834-28-6
Purity: >98%
Molecular Formula: C10H16ClN5
Molecular weight: 241.72
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Phenformin, an anti-diabetic drug, has demonstrated antitumor activity both in vitro and in vivo. IC50 Value: Target: Anticancer in vitro: Treatment with phenformin significantly delayed the development of resistance to PLX4720 in cultured melanoma cells. Biochemical analyses showed that phenformin and PLX4720 exerted cooperative effects on inhibiting mTOR signaling and inducing apoptosis. Noticeably, phenformin selectively targeted subpopulations of cells expressing JARID1B, a marker for slow cycling melanoma cells, whereas PLX4720 selectively targeted JARID1B-negative cells [1]. Phenformin also exhibited histone modification and was more effective than metformin in destabilizing MYC/MYCN in NB cells [2]. Phenformin activates UPR sensors IRE1alpha and pancreatic endoplasmic reticulum kinase (PERK) in both an ER-dependent and ER-independent manner. Mechanistically, AMP-activated protein kinase (AMPK) activation is required but not sufficient to initiate phenformin-mediated IRE1alpha and PERK activation, suggesting the involvement of additional factor(s) [3]. in vivo: The chronic treatment of female C3H/Sn mice with phenformin (2 mg/day) and diphenylhydantoin (2 mg/day) prolonged mean life span by 23 and 25%, respectively, and decreased spontaneous tumour incidence by 4.0 and 2.3 times, respectively [4]. Oral administration of 5--10 mg of an antidiabetic biguanide-phenformin (phenethyl-biguanide) for 2.5--5 months suppressed DMBA-induced mammary tumour development in rats considerably. Phenformin-treated rats revealed-a tendency towards a decrease in blood insulin level (radioimmunoassay) [5].
Safety information: