PI-103, Free Base [371935-74-9]
ORB153627
CAS Number371935-74-9
Product group Chemicals
Estimated Purity>99%
Molecular Weight348.36 g/mol
Overview
- SupplierBiorbyt
- Product NamePI-103, Free Base [371935-74-9]
- Delivery Days Customer16
- CAS Number371935-74-9
- CertificationResearch Use Only
- Estimated Purity>99%
- Molecular FormulaC19H16N4O3
- Molecular Weight348.36 g/mol
- Scientific DescriptionPI-103 is acts as a dual inhibitor of class IA phosphatidylinositide 3-kinase (PI3K) and mTOR. PIP3 activates Akt and mTOR, and plays important roles in cell growth and survival. PI-103 was mainly cytostatic for human leukemic cell lines and induced cell cycle arrest in the G1 phase. PI-103 inhibited endothelial cell proliferation and survival in vitro and tumor growth in vivo possibly by blocking activation of both PI3K and mTOR in vGPCR-expressing endothelial cells. PI-103 has been seen to have nominal effects inhibiting basal Na+ transport, but is very effective in abolishing insulin-induced Na+ absorption in the nephron.
- Storage Instruction-20°C or -80°C
- UNSPSC12352200