Chemical Structure
Chemical Structure
Pifithrin-alpha hydrobromide [63208-82-2]
AG-CR1-0004
Estimated Purity>98% (NMR)
Product group Chemicals
Molecular Weight286.4 . 80.9
Overview
- SupplierAdipoGen Life Sciences
- Product NamePifithrin-alpha hydrobromide [63208-82-2]
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity>98% (NMR)
- Hazard InformationNon-hazardous
- Molecular FormulaC16H18N2OS . HBr
- Molecular Weight286.4 . 80.9
- Scientific DescriptionChemical. CAS: 63208-82-2. Formula: C16H18N2OS . HBr. MW: 286.4 . 80.9. p53 inhibitor. Reversibly blocks p53-dependent transcriptional activation. Tool to combat side effects of cancer therapy. Apoptosis inhibitor. - p53 inhibitor [1, 2]. Reversibly blocks p53-dependent transcriptional activation [2]. Tool to combat side effects of cancer therapy [3]. Apoptosis inhibitor [1, 2, 4].
- SMILES[Br].CC1=CC=C(C=C1)C(=O)CN1C(=N)SC2=C1CCCC2
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352200
References
- A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy: P.G. Komarov, et al.; Science 285, 1733 (1999)
- Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation: P.J. Murphy, et al.; J. Biol. Chem. 279, 30195 (2004)
- Cancer research. A new way to combat therapy side effects: D. Ferber; Science 285, 1651 (1999)
- Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio: D. Javelaud & F. Besancon; J. Biol. Chem. 277, 37949 (2002)