PIK-75 hydrochloride [372196-77-5]

MedChem Express

PIK-75 hydrochloride [372196-77-5]

10

372196-77-5

Research Use Only

98%

C16H15BrClN5O4S

488.74

PIK-75 hydrochloride is a reversible DNA-PK and p110alpha-selective inhibitor, which inhibits DNA-PK, p110alpha and p110gamma with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 hydrochloride inhibits p110alpha >200-fold more potently than p110beta (IC50=1.3 microM). PIK-75 hydrochloride induces apoptosis.

BrC(C=C1)=CN2C1=NC=C2/C=N/N(S(=O)(C3=C(C=CC([N+]([O-])=O)=C3)C)=O)C.[H]Cl

2°C to 8°C,-20°C,-80°C

12352200