Pioglitazone HCl [112529-15-4]
S2046
Overview
- SupplierSelleck Chemicals
- Product NamePioglitazone HCl [112529-15-4]
- Delivery Days Customer9
- CAS Number112529-15-4
- CertificationResearch Use Only
- Scientific DescriptionPioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 muM, 11.8 muM and 32.1 muM, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist with EC50 of 0.93 muM and 0.99 muM for human PPARgamma and mouse PPARgamma, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.
- UNSPSC12352200