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Midostaurin [120685-11-2]

Research Use Only
HY-10230
MedChem Express
CAS Number120685-11-2
Product group Chemicals
Molecular Weight570.64
Price on request
Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Midostaurin [120685-11-2]
  • Delivery Days Customer
    10
  • CAS Number
    120685-11-2
  • Certification
    Research Use Only
  • Molecular Formula
    C35H30N4O4
  • Molecular Weight
    570.64
  • Scientific Description
    Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCalpha/beta/gamma, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRbeta and VEGFR1/2 with IC50s ranging from 22-500 nM. Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects.
  • SMILES
    O=C(C1=CC=CC=C1)N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2
  • Storage Instruction
    -20°C,-80°C
  • UNSPSC
    12352200