Plinabulin [714272-27-2]

MedChem Express

Plinabulin [714272-27-2]

10

714272-27-2

Research Use Only

98%

C19H20N4O2

336.39

Plinabulin (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells. Plinabulin binds the colchicine binding site of beta-tubulin preventing polymerization and has potent inhibitory to tumor cells.

O=C(N/C1=C\C2=C(NC=N2)C(C)(C)C)/C(NC1=O)=C/C3=CC=CC=C3

2°C to 8°C,-20°C,-80°C

12352200