Podophyllotoxin [518-28-5]

Catalog number: AG-CN2-0049-M100
Brand: AdipoGen Life Sciences
Packing: 100 mg
Price: € 45.00
Expected delivery time: 7 days
Chemical Structure

Product specifications for - Podophyllotoxin [518-28-5]

Product group: Chemicals
Category: Other
Source: Isolated from Podophyllum emodi rhizomes.
CAS No.: 518-28-5
Purity: >98% (HPLC)
Molecular Formula: C22H22O8
Molecular weight: 414.4
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Potent microtubule assembly inhibitor. Anticancer compound. Cell death inducer. DNA topoisomerase II inhibitor. Cell cycle inhibitor at the metaphase. Antiviral and antihelminthic.
Safety information: 
ADR klasse: 6; 1
UN Number: UN2811
Hazard information: H301, H310, H315, H319, H335
Additional information: 
Synonyms: AG-CN2-0049-M100; AdipoGen Life Sciences; Podofilox; NSC 24818; Podophyllinic acid lactone
VP16-213 and podophyllotoxin. A study on the relationship between chemical structure and biological activity: J.D. Loike; Cancer Chemother. Pharmacol. 7, 103 (1982) Read more
Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents: T. Terada, et al.; Chem. Pharmacol. Bull. (Tokyo) 40, 2720 (1992) Read more
Antineoplastic and antiviral activities of podophyllotoxin related lignans: M. Gordaliza, et al.; Arch. Pharmacol. 327, 175 (1994) Read more
Podophyllotoxin: C. Canel, et al.; Phytochemistry 54, 115 (2000) (Review) Read more
Antitumor properties of podophyllotoxin and related compounds: M. Gordaliza, et al.; Curr. Pharm. Des. 6, 1811 (2000) (Review) Read more
Drugs that inhibit tubulin polymerization: the particular case of podophyllotoxin and analogues: S. Desbene & S. Giorgi-Renault; Curr. Med. Chem. Anticancer Agents 2, 71 (2002) (Review) Read more
Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents: Y. You; Curr. Pharm. Des. 11, 1695 (2005) (Review) Read more
Camptothecin and podophyllotoxin derivatives: inhibitors of topoisomerase I and II - mechanisms of action, pharmacokinetics and toxicity profile: J.T. Hartmann & H.P. Lipp; Drug Saf. 29, 209 (2006) (Review) Read more
An evidence-based review of medical and surgical treatments of genital warts: N. Scheinfeld & D.S. Lehman; Dermatol. Online J. 12, 5 (2006) Read more