Pralatrexate [146464-95-1]

MedChem Express

Pralatrexate [146464-95-1]

10

146464-95-1

Research Use Only

95%

C23H23N7O5

477.47

Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor with a Ki of 13.4 pM. Pralatrexate is a substrate for folylpolyglutamate synthetase with improved cellular uptake and retention. Pralatrexate has antitumor activities and has the potential for relapsed/refractory T-cell lymphoma treatment.

O=C(CC[C@H](NC(C1=CC=C(C=C1)C(CC#C)CC2=NC3=C(N=C(N=C3N=C2)N)N)=O)C(O)=O)O

2°C to 8°C,-20°C,-80°C

12352200