Pralsetinib [2097132-94-8]

MedChem Express

Pralsetinib [2097132-94-8]

10

2097132-94-8

98.55%

C27H32FN9O2

533.6

Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor. Pralsetinib (BLU-667) inhibits WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion with IC50s of 0.4, 0.3, 0.4, 0.4, and 0.4 nM, respectively.

O=C([C@@]1(OC)CC[C@H](C2=NC(NC3=NNC(C)=C3)=CC(C)=N2)CC1)N[C@H](C4=CC=C(N5N=CC(F)=C5)N=C4)C

2°C to 8°C,-20°C,-80°C

12352200