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PROTAC Bcl2 degrader-1 [2378801-85-3]

HY-125876
MedChem Express
CAS Number2378801-85-3
Product group Chemicals
Estimated Purity98.54%
Molecular Weight941.84
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Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    PROTAC Bcl2 degrader-1 [2378801-85-3]
  • Delivery Days Customer
    10
  • CAS Number
    2378801-85-3
  • Estimated Purity
    98.54%
  • Molecular Formula
    C45H45BrN6O10S
  • Molecular Weight
    941.84
  • Scientific Description
    PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 microM; DC50, 3.0 microM) and Mcl-1 (IC50, 11.81 microM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.
  • SMILES
    O=C(NCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)CCCCC(NCCN4C(C5=C6C(C4=O)=CC=C(C6=CC=C5)SC7=CC=C(C=C7)Br)=O)=O
  • Storage Instruction
    -20°C,-80°C
  • UNSPSC
    12352200