Pseudolaric acid B [82508-31-4]

Catalog number: AG-CN2-0083-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Other sizes: 1 mg
Price: € 45.00
Expected delivery time: 7 days
Chemical Structure

Product specifications for - Pseudolaric acid B [82508-31-4]

Product group: Chemicals
Category: Other
Source: Isolated from Pseudolarix kaempferi.
CAS No.: 82508-31-4
Purity: >98% (HPLC)
Molecular Formula: C23H28O8
Molecular weight: 432.5
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Storage instructions: Store at +4°C
Scientific information: 
Scientific info: Antifungal and antifertility compound. Antitumor compound. PPARalpha signaling agonist. Angiogenesis inhibitor. Apoptosis and autophagy inducer. Microtubule-destabilizing agent. Anti-inflammatory. Inhibits NF-kappaB and p38 signaling. Immunosuppressive.
Safety information: 
ADR klasse: 6; 1
UN Number: UN2811
Hazard information: H301, H361
Additional information: 
Synonyms: AG-CN2-0083-C100; AdipoGen Life Sciences; Pseudolarix acid B; PLAB; PAB
Pseudolaric Acids from Pseudolarix kaempferi: B.N. Zhou, et al.; Planta Med. 47, 35 (1983) Read more
The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives: D.J. Pan, et al.; Planta Med. 56, 383 (1990) Read more
Antifungal evaluation of pseudolaric acid B, a major constituent of Pseudolarix kaempferi: E. Li, et al.; J. Nat. Prod. 58, 57 (1995) Read more
Pseudolaric acid analogs as a new class of peroxisome proliferator-activated receptor agonists: M.S. Jardat, et al.; Planta Med. 68, 667 (2002) Read more
Pseudolarix acid B inhibits angiogenesis by antagonizing the vascular endothelial growth factor-mediated anti-apoptotic effect: W.F. Tan, et al.; Eur. J. Pharmacol. 499, 219 (2004) Read more
Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation: M.H. Li, et al.; Clin. Cancer Res. 10, 8266 (2004) Read more
Pseudolaric acid B induces apoptosis through p53 and Bax/Bcl-2 pathways in human melanoma A375-S2 cells: X.F. Gong, et al.; Arch. Pharm. Res. 28, 68 (2005) Read more
Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo: V.K. Wong, et al.; Clin. Cancer Res. 11, 6002 (2005) Read more
Effect of pseudolaric acid B on gastric cancer cells: inhibition of proliferation and induction of apoptosis: K.S. Li, et al.; World J. Gastroenterol. 11, 7555 (2005) Read more
Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin: Y.G. Tong, et al.; Mol. Pharmacol. 69, 1226 (2006) Read more