Pyr10 [1315323-00-2]

MedChem Express

Pyr10 [1315323-00-2]

10

1315323-00-2

Research Use Only

99.42%

C18H13F6N3O2S

449.37

Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 microM (IC50 of 13.08 microM for store operated Ca2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels.

O=S(C1=CC=C(C)C=C1)(NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2)=O

2°C to 8°C,-20°C,-80°C

12352200