Q-VD-OPh [1135695-98-5]

Catalog number: AG-CP3-0006-M005
Brand: AdipoGen Life Sciences
Packing: 5 mg
Other sizes: 1 mg
3 x 1 mg
Price: € 650.00
Expected delivery time: 7 days
Quantity:
Chemical Structure
Chemical Structure...

Product specifications for - Q-VD-OPh [1135695-98-5]

Overview: 
Product group: Chemicals
Category: Other
Source: Synthetic.
CAS No.: 1135695-98-5
Properties: 
Purity: >95% (TLC)
Molecular Formula: C26H25F2N3O6
Molecular weight: 513.5
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6-difluorophenoxy methyl (OPh) group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies. - Chemical. CAS: 1135695-98-5 (anhydrous). Formula: C26H25F2N3O6. MW: 513.5. Synthetic. Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6-difluorophenoxy methyl (OPh) group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies.
Safety information: 
MSDS: MSDS
Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties: T.M. Caserta, et al.; Apoptosis 8, 345 (2003) Read more
Specific caspase inhibitor Q-VD-OPh prevents neonatal stroke in P7 rat: a role for gender: S. Renolleau, et al.; J. Neurochem. 100, 1062 (2007) Read more
The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities: T.T. Rohn; Apoptosis 15, 1403 (2010) Read more
The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells: X. Chen-Deutsch, et al.; Leuk. Res. 36, 884 (2012) Read more