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Chemical Structure
Chemical Structure
Chemical Structure

(R)-CR8 [294646-77-8]

Research Use Only
AG-CR1-0039
AdipoGen Life Sciences
CAS Number294646-77-8
Product group Chemicals
Estimated Purity>98% (NMR)
Molecular Weight431.5
Price on request
Packing Size
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    (R)-CR8 [294646-77-8]
  • Delivery Days Customer
    10
  • CAS Number
    294646-77-8
  • Certification
    Research Use Only
  • Estimated Purity
    >98% (NMR)
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C24H29N7O
  • Molecular Weight
    431.5
  • Scientific Description
    Chemical. CAS: 294646-77-8. Formula: C24H29N7O. MW: 431.5. Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor. Apoptosis inducer. Potent glycogen synthase kinase (GSK-3alpha/beta) inhibitor. - Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor [1]. Apoptosis inducer [1]. Potent glycogen synthase kinase (GSK-3alpha/beta) inhibitor [1].
  • SMILES
    CC[C@H](CO)NC1=NC2=C(N=CN2C(C)C)C(NCC2=CC=C(C=C2)C2=NC=CC=C2)=N1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases: K. Bettayeb, et al.; Oncogene 27, 5797 (2008)
  • Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice: H. Sallam, et al.; BMC Pharmacol. Toxicol. 14, 50 (2013)
  • Inhibition of NF-kappaB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells: E. Cosimo, et al.; Clin. Cancer Res. 19, 2393 (2013)