Raltegravir (MK-0518) [518048-05-0]

Selleck Chemicals

Raltegravir (MK-0518) [518048-05-0]

9

518048-05-0

Research Use Only

Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively. It shows greater than 1000-fold selectivity for HIV-1 IN over several related Mg2+-dependent enzyme such as HCV polymerase, HIV reverse transcriptase, HIV RNaseH and human alfa-, bèta-, gamma-polymerases.

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