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Rhosin hydrochloride [1281870-42-5]

Research Use Only
HY-12646
MedChem Express
CAS Number1281870-42-5
Product group Chemicals
Estimated Purity99.67%
Molecular Weight394.86
Price on request
Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Rhosin hydrochloride [1281870-42-5]
  • Delivery Days Customer
    10
  • CAS Number
    1281870-42-5
  • Certification
    Research Use Only
  • Estimated Purity
    99.67%
  • Molecular Formula
    C20H19ClN6O
  • Molecular Weight
    394.86
  • Scientific Description
    Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride induces cell apoptosis. Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability.
  • SMILES
    O=C(N/N=C/C1=CC=C2N=CC=NC2=C1)[C@H](N)CC3=CNC4=C3C=CC=C4.[H]Cl
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200