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ProductsBack/RO-3306 [872573-93-8]
Chemical Structure
Chemical Structure
Chemical Structure

RO-3306 [872573-93-8]

Research Use Only
AG-CR1-3515
AdipoGen Life Sciences
CAS Number872573-93-8
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Product group Chemicals
Estimated Purity>95% (NMR)
Molecular Weight351.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    RO-3306 [872573-93-8]
  • Delivery Days Customer
    10
  • CAS Number
    872573-93-8
  • Certification
    Research Use Only
  • Estimated Purity
    >95% (NMR)
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C18H13N3OS2
  • Molecular Weight
    351.5
  • Scientific Description
    Chemical. CAS: 872573-93-8. Formula: C18H13N3OS2. MW: 351.5. Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M . Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards. - Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A) [1-3, 5]. Potential anti-cancer compound [1, 8]. Cell cycle arrest inducer at G1, S and G2/M [2, 7] . Apoptosis inducer in embryonic stem cells [4]. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines [6]. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387 [8, 9]. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards [9].
  • SMILES
    O=C1N=C(NCC2=CC=CS2)S\C1=C/C1=CC2=C(C=C1)N=CC=C2
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1: L.T. Vassilev, et al.; PNAS 103, 10660 (2006)
  • Cell cycle synchronization at the G2/M phase border by reversible inhibition of CDK1: L.T. Vassilev; Cell Cycle 5, 2555 (2006)
  • Selective chemical inhibition as a tool to study Cdk1 and Cdk2 functions in the cell cycle: L. Krasinska, et al.; Cell Cycle 7, 1702 (2008)
  • Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity: Z. Ullah, et al.; Genes Dev. 22, 3024 (2008)
  • Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis: H.T. Ma, et al.; Mol. Cell Biol. 29, 6500 (2009)
  • Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML: K. Kojima, et al.; Cancer Sci. 100, 1128 (2009)
  • Differential roles of STIM1, STIM2 and Orai1 in the control of cell proliferation and SOCE amplitude in HEK293 cells: C. El Boustany, et al.; Cell Calcium 47, 350 (2010)
  • Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells: N.N. Kreis, et al.; Oncogene 29, 5591 (2010)
  • Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity: Y. Matthess, et al.; Mol. Cell Biol. 30, 5726 (2010)