Ro 67-7476 [298690-60-5]

MedChem Express

Ro 67-7476 [298690-60-5]

10

298690-60-5

98.54%

C17H18FNO2S

319.39

Ro 67-7476 is a potent positive allosteric modulator of mGluR1 and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC50 of 60.1 nM. Ro 67-7476 is a potent P-ERK1/2 agonist and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50=163.3 nM).

O=S(N1[C@H](C2=CC=C(F)C=C2)CCC1)(C3=CC=C(C)C=C3)=O

2°C to 8°C,-20°C,-80°C

12352200