Romidepsin

Catalog number: R425060_25mg
Brand: Toronto Research Chemicals
Packing: 25 mg
Other sizes: 500 ug
1 mg
2 mg
5 mg
10 mg
Price: On Request
Expected delivery time: 21 days
Quantity:

Product specifications for - Romidepsin

Overview: 
Product group: Chemicals
Category: Other
CAS No.: 128517-07-7
Properties: 
Molecular Formula: C24H36N4O6S2
Molecular weight: 540,7
Melting point: 219-224°C
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Form supplied: White to Off-White Solid
Storage instructions: Amber Vial, -20°C Freezer, Under Inert Atmosphere
Scientific information: 
Scientific info: Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti-proliferative activity in vitro against multiple mouse and human tumor cell lines and in vivo in human tumor xenograft models. Romidepsin can be administered with a second agent, such as a cytotoxic agent, a steroidal agent, a proteasome inhibitor, or a kinase inhibitor.
Additional information: 
Synonyms: R425060; Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl] Cyclic (35)-Disulfide; [S-(E)]-N-(3-Hydroxy-7-mercapto-1-oxo-4- heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aminobutanoyl-L-valine (4-1)-Lactone Cyclic (12)-Disulfide; Antibiotic FR 901228; Chromadax; FK 228; FR 901228; NSC 630176