RQ-00203078 [1254205-52-1]

MedChem Express

RQ-00203078 [1254205-52-1]

10

1254205-52-1

Research Use Only

99.74%

C21H13ClF6N2O5S

554.85

RQ-00203078 is a highly selective, potent and orally active TRPM8 antagonist with IC50s of 5.3 nM and 8.3 nM for rat and human TRPM8 channels, respectively. RQ-00203078 shows little inhibitory action against TRPV1, TRPA1, TRPV4, or TRPM2 channels.

O=C(O)C1=CC=C(S(=O)(N(C2=NC=C(C(F)(F)F)C=C2Cl)CC3=CC=C(OC(F)(F)F)C=C3)=O)C=C1

2°C to 8°C,-20°C,-80°C

12352200