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ProductsBack/Rugulosin [23537-16-8]
Chemical Structure
Chemical Structure
Chemical Structure

Rugulosin [23537-16-8]

Research Use Only
AG-CN2-0124
AdipoGen Life Sciences
CAS Number23537-16-8
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Product group Chemicals
Estimated Purity>95% (HPLC)
Molecular Weight542.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Rugulosin [23537-16-8]
  • Delivery Days Customer
    10
  • CAS Number
    23537-16-8
  • Certification
    Research Use Only
  • Estimated Purity
    >95% (HPLC)
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C30H22O10
  • Molecular Weight
    542.5
  • Scientific Description
    Antibiotic [1]. Antibacteriophage. Antiviral [2]. Mycotoxin [3]. DNA replication, transcription and repair inhibitor [4]. Antibacterial [5]. RNA polymerase and ribonuclease H inhibitor [6]. Insecticidal. Cytotoxic [7]. HIV-1 integrase inhibitor [8]. Shows anti-MRSA (methicillin-resistant Staphylococcus aureus) activity [9]. Potential Hsp90 inhibitor through interacting with N-Hsp90 [10]. - Chemical. CAS: 23537-16-8. Formula: C30H22O10. MW: 542.5. Isolated from Penicillium sp. Antibiotic. Antibacteriophage. Antiviral. Mycotoxin. DNA replication, transcription and repair inhibitor. Antibacterial. RNA polymerase and ribonuclease H inhibitor. Insecticidal. Cytotoxic. HIV-1 integrase inhibitor. Shows anti-MRSA (methicillin-resistant Staphylococcus aureus) activity. Potential Hsp90 inhibitor through interacting with N-Hsp90.
  • SMILES
    CC1=CC2=C(C(O)=C1)C(=O)C1=C(O)[C@H]3C(O)C4C5C(O)[C@H](C(O)=C6C(=O)C7=C(O)C=C(C)C=C7C(=O)C356)C14C2=O
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Studies in the biochemistry of micro-organisms. 95. Rugulosin, a crystalline colouring matter of Penicillium rugulosum Thom: J. Breen, et al.; Biochem. J. 60, 618 (1955)
  • Inhibition of phage growth by an antibiotic rugulosin isolated from Myrothecium verucaria. I. Properties of the anti-phage effect: S. Nakamura, et al.; Jpn. J. Microbiol. 15, 113 (1971)
  • Toxicological approach to (+) rugulosin, an anthraquinoid mycotoxin of Penicillium rugulosum Thom: Y. Ueno, et al.; Jpn. J. Exp. Med. 41, 177 (1971)
  • Specific and non-specific interactions of two carcinogenic mycotoxins, luteoskyrin and rugulosin with nucleic acids: J.C. Bouhet, et al.; Ann. Nutr. Aliment. 31, 811 (1977)
  • Mutagenicity and antibacterial activity of mycotoxins produced by Penicillium islandicum Sopp and Penicillium rugulosum: A.A. Stark, et al.; J. Environ. Pathol. Toxicol. 2, 313 (1978)
  • Inhibitory effects of carcinogenic mycotoxins on deoxyribonucleic acid-dependent ribonucleic acid polymerase and ribonuclease H: F. Tashiro, et al.; Appl. Environ. Microbiol. 38, 191 (1979)
  • Cytotoxicity against insect cells of entomopathogenic fungi of the genera Hypocrella (anamorph Aschersonia): possible agents for biological control: P. Watts, et al.; Mycol. Res. 107, 581 (2003)
  • Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites: S.B. Singh, et al.; J. Ind. Microbiol. Biotechnol. 30, 721 (2003)
  • New rugulosins, anti-MRSA antibiotics, produced by Penicillium radicum FKI-3765-2: H. Yamazaki, et al.; Org. Lett. 12, 1572 (2010)
  • Inhibition and binding of Rugulosin with N-Hsp90: J.-J.Chen, et al.; Gaodeng Xuexiao Huaxue Xuebao 32, 88 (2011)