S1RA hydrochloride [1265917-14-3]

MedChem Express

S1RA hydrochloride [1265917-14-3]

10

1265917-14-3

Research Use Only

99.85%

C20H24ClN3O2

373.88

S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (sigma1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against sigma2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 microM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization.

CC1=CC(OCCN2CCOCC2)=NN1C3=CC(C=CC=C4)=C4C=C3.[H]Cl

2°C to 8°C,-20°C,-80°C

12352200